We work to identify and validate new targets in oncology.
 
Our objective is to discover innovative and personalized cancer therapies.

what we do

Key interests:

Cancer Biology, Developmental Biology, RNA biology, Epigenetics, Post-Transcriptional Processing, Antisense Oligonucleotides, Methyltransferases.

Target identification and Validation

The Guccione lab has a long-standing interest in understanding basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology.

 

Currently, we are interested in the function in development and disease of Protein MethylTransferases (i.e. PRMTs and PRDMs) and in modulation of Alternative Splicing using Antisense Oligonucleotide (AON)-based approaches.

 

We use biochemistry, mouse models and next generation sequencing techniques to understand the molecular mechanisms of action of candidate PMTs or specific isoforms. The range of techniques and approaches used in the lab has allowed us to characterize the mechanism of action of specific PMTs (e.g. PRMT5 and PRMT6) or oncogenic isoforms (e.g. MDM4l/s), which are now of great interest for their clinical applications.

 
 

THe TEAM

ErnestoPhoto1-1.jpg

Ernesto Guccione

Principal Investigator

0.jpg

Alex Rialdi 

Post Doc

Slim_Mzoughi.jpg

Slim Mzoughi

Associate Scientist

JuliaZhao2-150x150.jpg

Julia Zhao 

PhD Student

tommi.jpg

Tommaso Tabaglio 

Co-Founder ImmuNOA

Co-Founder TechNOA

0-2_edited.jpg

Megan Schwarz

PhD Student

0-1_edited.jpg

Federico Di Tullio

PhD Student

Denis Torre

PhD Student

Monzia Moodie

Associate Researcher/

Lab Manager

Monzia eglab.jpg
denis_eglab(1).png
CONTACT

Hess CSM Building Floor 6th Room 108 1470 Madison Ave New York, NY 10029

Phone: +1 (212) 824-9352

ernesto.guccione@mssm.edu

Thanks for submitting!