
We work to identify and validate new targets in oncology.
Our objective is to discover innovative and personalized cancer therapies.
what we do
Key interests:
Cancer Biology, Developmental Biology, RNA biology, Epigenetics, Post-Transcriptional Processing, Antisense Oligonucleotides, Methyltransferases.
Target identification and Validation
The Guccione lab has a long-standing interest in understanding basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology.
Currently, we are interested in the function in development and disease of Protein MethylTransferases (i.e. PRMTs and PRDMs) and in modulation of Alternative Splicing using Antisense Oligonucleotide (AON)-based approaches.
We use biochemistry, mouse models and next generation sequencing techniques to understand the molecular mechanisms of action of candidate PMTs or specific isoforms. The range of techniques and approaches used in the lab has allowed us to characterize the mechanism of action of specific PMTs (e.g. PRMT5 and PRMT6) or oncogenic isoforms (e.g. MDM4l/s), which are now of great interest for their clinical applications.

THe TEAM
Ernesto Guccione
Principal Investigator

Alex Rialdi
Post Doc

Slim Mzoughi
Associate Scientist

Julia Zhao
PhD Student


Megan Schwarz
PhD Student

Federico Di Tullio
PhD Student
Denis Torre
PhD Student
Monzia Moodie
Associate Researcher/
Lab Manager

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CONTACT
Hess CSM Building Floor 6th Room 108 1470 Madison Ave New York, NY 10029
Phone: +1 (212) 824-9352